One-pot, three component synthesis of 2,4,5-trisubstituted imidazoles using environmentally friendly sources of ammonia

Lanthanum chloride was found to be an excellent catalyst for the synthesis of 2,4,5-trisubstituted imidazoles via microwave-promoted, one-pot reaction of an aldehyde, a 1,2-diketone and guanidine (or urea, thiourea) under solvent-free condition. This method elucidates guanidine, urea or thiourea as an environmentally benign source of ammonia for the synthesis of 2,4,5-trisubstituted imidazoles.

کلیدواژه ها:

Imidazole ، Aldehyde ، 1 ، 2-Diketone ، Solvent-free conditions ، Lanthanum chloride ، Microwave-assisted