Microextraction of Atorvastatin in biological sample using hollow fiber combined with high performance liquid chromatography

The use of hollow fiber membrane microextraction in analytical chemistry has been increasing as the techniqueis a simple and efficient method for the extraction of trace organic compounds from environmental matrices. Inthis paper, a three phase hollow fiber-based liquid phase microextraction (HF-LPME) combined with a HPLCprocedure using UV-Vis detection has been developed for the determination of atorvastatin in biological sample.A Q3/2 Accurel PP polypropylene hollow fiber supporting 1-octanol was used between two aqueous solution(pH 4) as donor phase and (pH 11) as acceptor phase. Parameters such as extraction solvent, agitation of thesample, salt addition and extraction time were controlled and optimized. The proposed method was applied tothe determination of the analyte in human urine and in environmental water and urine samples

کلیدواژه ها:

Hollow fiber liquid phase microextraction ، HPLC ، Atorvastatin